Maturation rapidly achieved for peptides and proteins through directed or random mutagenesis techniques. Multiple methods exist for the library generation and improved candidates are be rapidly obtained. Large library sizes enable greater sequence space to be searched than any other maturation method.

 

 

Biological activity is often improved with affinity. Multiple maturation libraries can be screened so that a global minimum structures rather than a local minimum in the sequence space can be found. This leads to greater activity.

 

 

Stability to proteases can be engineered so that the intrinsic pharmacokinetics of the peptide of protein can be improved. Novel and natural human peptides can be stabilized using this technique.

 

 

Isogenica can advise on formulations for pK enhancement for the progression of candidate proteins through early development.