Isogenica

Isogenica Human Library

Alexandria™ - Next generation fully synthetic human Fab antibody fragment library

Isogenica’s fully synthetic human Fab antibody fragment library takes advantage of data derived from the mass sequencing of natural repertoires and the structural resolution of antibody-antigen interactions. These data resources allowed our designers to accommodate the local structural environment within the variable domains. This maximises active functional diversity and minimises post-translational liabilities.

Advantages

  • Fully variable Heavy and Light chain repertoires, as well as Common Light Chain
  • Fab format fully synthetic libraries with unrivalled level of manufacturing scale-up pre-optimization
  • Useful for conventional mAbs, bispecific antibodies, TandAb and related novel antibody formats
  • Designed using empirical data from the mass sequencing of natural repertoires and the structural resolution of antibody-antigen interactions