Single Domain Biotherapeutics

Humanized single domains for direct therapeutics and targeted delivery.

LlamdA® Antibodies

LlamdA® VHH are humanized monovalent antibodies.

LlamdA VHH Libraries

Small in size (15 kD), biophysically robust and with tunable half-lives these antibodies are ideal for targeting inaccessible epitopes, achieving enhanced tissue penetration, multi-target binding and formatting for payload delivery.

LlamdA® is Isogenica’s proprietary fully synthetic single domain VHH library, built with our precision COLIBRA® technology to eliminate liabilities and provide biophysically robust therapeutic antibodies.

What are

VHH?

In the early 1990’s researchers discovered that camels and llamas produce heavy-chain only antibodies.

Their small size, high stability and full antigen binding capacity identified them as potentially excellent building blocks for novel non- IgG biotherapeutics.

In 2019 the first VHH biotherapy received FDA approval. Originally discovered and developed by Ablynx, Caplacizumab gained regulatory approval in February 2019. New approvals are expected imminently with a significant and growing pipeline of VHH therapeutics in clinical development.

VHH Antibody Libraries