Isogenica have developed fully synthetic, in vitro plug-and-play cassette-based approach to efficiently generate combinations of bi- and tri-specific VHH and have exemplified this in in vitro studies.

• Isogenica’s libraries ensure standardised flanking sequences that can be easily slotted into bi- and tri-specific expression cassettes
• Cross-species specific anti-albumin VHH binds to protein A to simplify downstream CMC
• Production in mammalian expression systems and scaled-up purification facilitates developability and functional testing, including T-cell activation